Also, people with compromised immune systems and impaired health are more likely to get it. It can be difficult to maintain weight loss even when one is on a diet. It can affect the nail bed matrix, plate, or nail bed. Everyone wants flawless, healthy skin that is free from wrinkles and scarring. This is an infection of the dead skin tissue or nails. A podiatrist may recommend that the toenail be removed if it is infected or recurring. People with weakened immune system are more susceptible to infections, including toenail fungal disease.